报 告 人： 刘新峰 教授
美国南卡罗来纳大学 博士生导师
报告题目：Computational studies for cancer cell lineage models and cell signaling
报告时间：
报告地点：静远楼1508学术报告厅
主办单位：数学与统计学院、科技处
报告摘要：For the first part of this talk, I shall introduce mathematical modeling for the dynamical interaction between cancer stem cells (CSCs) and non-stem cancer cells, and our findings reveal that two negative feedback loops are critical in controlling the balance between the population of CSCs and that of non-stem cancer cells. Furthermore, the model with negative feedback suggests that over-expression of the oncogene HER2 leads to an increase of CSCs by regulating the division mode or proliferation rate of CSCs. Scaffold, a class of proteins, plays many important roles in signal transduction. For the second part of my talk, through studying various models of scaffold, I will show novel regulations induced by scaffold binding in a multi-site phosphorylation system and with scaffold's spatial localization. To efficiently compute the models, we introduce a new class of fast numerical algorithm incorporated with adaptive mesh refinement and WENO scheme for solving the stiff systems with spatial dynamics.
刘新峰教授简介：
刘新峰，1997年复旦大学本科毕业，2000年东南大学硕士毕业，2006年美国纽约州立大学石溪分校博士。2006－2009年美国加州大学尔湾分校访问助理教授，2009－2013年南卡罗来纳大学助理教授，2013年至今为南卡罗来纳大学终身副教授。发表20多篇学术论文，单独主持两项美国自然科学基金项目，单独主持一项南卡大学基金项目，共同主持两项南卡州立基金项目。